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教师信息

蔡德敏
发布日期:2019-11-22浏览次数:字号:[ ]
 

  1. 学习经历

2014.09 – 2015.09 美国加州大学戴维斯分校 联合培养博士, 生化与分子医学专业.

2012.09 – 2015.11 南京农业大学,农业部动物生理生化重点实验室,博士,动物生理生化专业.

2009.09 – 2012.07 河南农业大学,农业部动物生化与营养重点实验,硕士,动物生理生化专业

2005.09 – 2009.07 扬州大学,兽医学院 本科,动物医学

2.工作经历

2019.11-             扬州大学 特聘教授

2019.01 - 2019.10     美国加州大学戴维斯分校 助理科学家(Faculty)

2016.03 – 2019.01     美国加州大学戴维斯分校 博士后

2015.12 – 2016.02     瑞典农业科学大学, 动物科技学院,访问学者

3.荣誉称号和社会任职

(1) 201723届美国加州大学戴维斯分校医学中心学术年会报告一等奖

(2) 美国 2016 Movement-PCF challenge award

(3) 2015长三角研究生论坛学术论文一等奖

(4) 2014博士研究生国家奖学金

(5) 2013 南京农业大学韩正康奖学金

(6) 2013 河南省第二届自然科学学术奖学术论文二等奖

(7) 2012 河南省优秀硕士研究生毕业论文奖

(8) 2012河南农业大学优秀硕士毕业生

主要学术兼职

美国动物科学协会(ASAS)会员,美国癌症协会会员AACR)。 EC nutrition 编委; Frontiers in Veterinary Science特邀编辑。Cancer Letters Scientific ReportsMolecular Nutrition and Food Research European Journal of Nutrition NutrientsInternational Journal of Molecular SciencesEpigenomes Metabolites期刊审稿人。

4.研究方向

(1) 动物分子营养学; 单胃动物营养生理

(2) 营养基因组学;表观遗传学

(3) 比较医学:生物节律/核受体参与的脂质代谢调控

5.科研项目

(1) 扬州大学高层次人才启动资金。2019.11-

(2) Movember Foundation-PCF Challenge Award. Targeting ROR-gamma with Novel Therapeutics for Lethal Prostate Cancer. 100万美元。08/2016-08/2018。青年科学家。

(3) 江苏省普通高校研究生科研创新计划“母体营养影响新生仔猪糖代谢的发生机制”(2013CXLX13_292)。2万。2013-2014。主持。

(4) 美国国立卫生院(NIH/NCI)。Therapeutic targeting of orphan NR in ER-negative breast cancerR01CA224900)”216 美元。11/08/2018-9/30/2023. Key investigator

(5) 美国国立卫生院(NIH/NCI)。“Targeting key orphan nuclear receptor in lethal prostate cancerRO1CA206222)”。196 美元。03/08/2016-02/28/2021. Key investigator

(6) US Department of Veterans Affairs VA BLR&D MERIT award. Novel epigenetic regulators in cancer resistance and as new targets I01BX002237-01)”。163万美元。 04/01/2014-02/28/2018Key investigator

(7) 美国国防部Department of Defense DoD)“An NR axis as a novel determinate d of AR in CRPCPC150758)”。59万美元。07/01/2016-06/30/2019. Key investigator

(8) 科技部“973”项目子课题“母体营养影响子代肉品质的代谢程序化机制(2012CB124703)”。 450万。2012-2016。主要参与。

6.代表性论文,著作与专利

(1) Cai D, Wang J, Gao B, Li J, Wu F, Zou JX, Xu J, Jiang Y, Zou H, Huang Z, Borowsky AD, Bold RJ, Lara PN, Li JJ, Chen X, Lam KS, To KF, Kung HJ, Fiehn O, Zhao R, Evans RM, Chen HW. RORγ is a targetable master regulator of cholesterol biosynthesis in a cancer subtype. Nat Commun. 2019 Oct 11;10(1):4621. 综合一区, IF: 11.87

(2) Wang J, Zou JX, Xue X, Cai D, Zhang Y, Duan Z, Xiang Q, Yang JC, Louie MC, Borowsky AD, Gao AC, Evans CP, Lam KS, Xu J, Kung HJ, Evans RM, Xu Y, Chen HW. ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer. Nat Med. 2016 May;22(5):488-96. (医学一区IF: 30.36)

(3) Cong R, Qu X, Zhang H, Hu Y, Ye S, Cai D*, Li X, Liu HY. Maternal high-protein diet modulates hepatic growth axis in weaning piglets by reprogramming the IGFBP-3 gene. Eur J Nutr. 2019 Sep 30( * 通讯作者, 营养学二区, IF: 4.45).

(4) Liu HY, Walden TB, Cai D*, Ahl D, Bertilsson S, Phillipson M, Nyman M, Holm L. Dietary Fiber in Bilberry Ameliorates Pre-Obesity Events in Rats by Regulating Lipid Depot, Cecal Short-Chain Fatty Acid Formation and Microbiota Composition. Nutrients. 2019 Jun 15;11(6). pii: E1350. (* 通讯作者, 营养学二区, IF: 4.17)

(5) Cai D, Wang J, Jia Y, Liu H, Yuan M, Dong H, Zhao R. Gestational dietary betaine supplementation suppresses hepatic expression of lipogenic genes in neonatal piglets through epigenetic and glucocorticoid receptor-dependent mechanisms. BBA-MOL CELL BIOL L. 2016 Jan;1861(1):41-50. (生物学二区, IF:5.55)

(6) Cai D, Yuan M, Jia Y, Liu H, Hu Y, Zhao R. Maternal gestational betaine supplementation-mediated suppression of hepatic cyclin D2 and presenilin1 gene in newborn piglets is associated with epigenetic regulation of the STAT3-dependent pathway. J Nutr Biochem. 2015 Dec;26(12):1622-31. 营养学一区, IF:4.68

(7) Cai D, Yuan M, Liu H, Han Z, Pan S, Yang Y, Zhao R. Epigenetic and SP1-mediated regulation is involved in the repression of galactokinase 1 gene in the liver of neonatal piglets born to betaine-supplemented sows. Eur J Nutr. 2017 Aug;56(5):1899-1909. (营养学二区, IF: 4.42)

(8) Cai D, Yuan M, Liu H, Pan S, Ma M Hong J, Zhao R. Maternal Betaine Supplementation throughout Gestation and Lactation Modifies Hepatic Cholesterol Metabolic Genes in Weaning Piglets via AMPK/LXR-Mediated Pathway and Histone Modification. Nutrients. 2016 October. (营养学二区, IF: 3.76)

(9) Cai D, Jia Y, Lu J, Yuan M, Sui S, Song H, Zhao R. Maternal dietary betaine supplementation modifies hepatic expression of cholesterol metabolic genes via epigenetic mechanisms in newborn piglets. Br J Nutr. 2014 Nov 14;112(9):1459-68. (营养学二区, IF: 3.34)

(10) Cai D, Jia Y, Song H, Sui S, Lu J, Jiang Z, Zhao R. Betaine supplementation in maternal diet modulates the epigenetic regulation of hepatic gluconeogenic genes in neonatal piglets. PLoS One. 2014 Aug 25;9(8):e105504. (综合三区, IF: 3.53)

(11) Cai D, Liu H, Zhao R. Nuclear receptors in hepatic glucose and lipid metabolism during neonatal and adult life. Curr Protein Pept Sci. 2016 Jun 26. (生物学三区, IF: 3.15)

(12) Cai D, Liu H, Yuan M, Pan S, Jia Y, Zhao R. Expression of hepatic miRNAs targeting porcine glucocorticoid receptor (GR) 3'UTR in the neonatal piglets under a maternal gestational betaine supplementation. Data Brief. 2015 Nov 26;6:4-7.  

(13) Cai D, Li H, Zhou B, Han L, Zhang X, Yang G, Yang G. Conjugated linoleic acid supplementation caused reduction of Perilipin1 and aberrant lipolysis in epididymal adipose tissue”. Biochem Biophys Res Commun. 2012 Jun 15;422(4):621-6. (生物学三区, IF: 2.48)

(14) Cai D, Zhang X and Chen H. TNBC co-option of a new master regulator of cholesterol biosynthesis provides a unique therapeutic opportunity. 2019. Molecular & Cellular Oncology.

(15) Wang J, Wang H, Wang LY, Cai D, Duan Z, Zhang Y, Chen P, Zou JX, Xu J, Chen X, Kung HJ, Chen HW. Silencing the epigenetic silencer KDM4A for TRAIL and DR5 simultaneous induction and antitumor therapy. Cell Death Differ. 2016 Sep 9. (生物学一区, IF: 8.22)

(16) Zhang X, Yang R, Jia Y, Cai D, Zhou B, Qu X, Han H, Xu L, Wang L, Yao Y, Yang G.  “Hypermethylation of Sp1 binding site links postnatal suppression of hypothalamic POMC gene and metabolic changes: impact of maternally dietary CLA”. Diabetes. 2014 May; 63(5):1475-87.医学一区, IF: 8.47

其他合作论文

(1) Pan S, Jia Y, Yang X, Cai D, Liu Z, Song H, Zhao R.Amino acid starvation-induced autophagy is involved in reduced subcutaneous fat deposition in weaning piglets derived from sows fed low-protein diet during gestation and lactation : Autophagy is involved in reduced fat deposition in maternal low-protein piglets. Eur J Nutr. 2018 Apr;57(3):991-1001.

(2) Ma W, Lu J, Jiang S, Cai D, Pan S, Jia Y, Zhao R. Maternal protein restriction depresses the duodenal expression of iron transporters and serum iron level in male weaning piglets. Br J Nutr. 2017 Apr;117(7):923-929.

(3) Jia Y, Hong J, Li H, Hu Y, Jia L, Cai D, Zhao R. Butyrate stimulates adipose lipolysis and mitochondrial oxidative phosphorylation through histone hyperacetylation-associated β3 -adrenergic receptor activation in high-fat diet-induced obese mice.Exp Physiol. 2017 Feb 1;102(2):273-281.

(4) Hu Y, Sun Q, Liu J, Jia Y, Cai D, Idriss AA, Omer NA, Zhao R. In ovo injection of betaine alleviates corticosterone-induced fatty liver in chickens through epigenetic modifications. Sci Rep. 2017 Jan 6;7:40251.

(5) Yang Y, Li X, Sun Q, He B, Jia Y, Cai D, Zhao R. Folate deprivation induces cell cycle arrest at G0/G1 phase and apoptosis in hippocampal neuron cells through down-regulation of IGF-1 signaling pathway. Int J Biochem Cell Biol. 2016 Oct; 79:222-230.

(6) Hong J, Jia Y, Pan Sh, Jia L, Li H, Han Zh, Cai D, Zhao R. Butyrate alleviates high fat diet-induced obesity through activation of adiponectin-mediated pathway and stimulation of mitochondrial function in the skeletal muscle of mice. Oncotarget. 2016 Aug 12. 

(7) Jia Y, Song H, Gao G, Cai D, Yang X, Zhao R. Maternal Betaine Supplementation during Gestation Enhances Expression of mtDNA-Encoded Genes through D-Loop DNA Hypomethylation in the Skeletal Muscle of Newborn Piglets. J Agric Food Chem. 2015 Nov 25;63(46):10152-60. PMID: 26527363

(8) Pan S, Yang X, Jia Y, Li Y, Chen R, Wang M, Cai D, Zhao R. Intravenous injection of microvesicle-delivery miR-130b alleviates high-fat diet-induced obesity in C57BL/6 mice through translational repression of PPAR-γ.J Biomed Sci. 2015 Oct 16;22:86.PMID: 26475357

(9) Jia Y, Gao G, Song H, Cai D, Yang X, Zhao R. Low-protein diet fed to crossbred sows during pregnancy and lactation enhances myostatin gene expression through epigenetic regulation in skeletal muscle of weaning piglets. Eur J Nutr. 2016 Apr;55(3):1307-14. PMID: 26066356

(10) Hu Y, Sun Q, Li X, Wang M, Cai D, Li X, Zhao R. In Ovo injection of betaine affects hepatic cholesterol metabolism through epigenetic gene regulation in newly hatched chicks. PLoS One. 2015 Apr 10;10(4):e0122643. PMID: 25860502

(11) Li X, Sun Q, Li X, Cai D, Sui S, Jia Y, Song H, Zhao R. Dietary betaine supplementation to gestational sows enhances hippocampal IGF2 expression in newborn piglets with modified DNA methylation of the differentially methylated regions. Eur J Nutr. 2015 Oct;54(7):1201-10. PMID: 25410747

(12) Sui S, Jia Y, He B, Li R, Li X, Cai D, Song H, Zhang R, Zhao R. Maternal Low-protein Diet Alters Ovarian Expression of Folliculogenic and Steroidogenic Genes and Their Regulatory MicroRNAs in Neonatal Piglets. Asian-Australas J Anim Sci. 2014 Dec;27(12):1695-704. PMID: 25358362

(13) Sui S, He B, Jia Y, Li R, Cai D, Li X, Song H, Jia L, Zhao R. Maternal protein restriction during gestation and lactation programs offspring ovarian steroidogenesis and folliculogenesis in the prepubertal gilts. J Steroid Biochem Mol Biol. 2014 Sep;143:267-76. PMID: 24787658

著作

Book chapter: Cai D, Liu H, Hu Y, Jiang Y, and Zhao R. Gestational Betaine, Liver Metabolism, and Epigenetics”. Handbook of Nutrition, Diets and Epigenetics. Springer Nature; 2017 July; pp1-14. 10.1007/978-3-319-31143-2_82-1

专利

“Methods for treating cancer with rorgamma inhibitors”. Hongwu Chen, June X.Zou, Junjian Wang, Demin Cai, Yong Xu, Xiaoqian Xue, Yan Zhang. 申请号:PCT/US2017/013966 发表号:WO2017127442 A120170717

 

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